Dr-Joshua-Muli

Position: Lecturer
Department: Zoological Sciences
Contact Address: P.O. Box 43844-00100, Nairobi, Kenya
Email: This email address is being protected from spambots. You need JavaScript enabled to view it., This email address is being protected from spambots. You need JavaScript enabled to view it.
Area of Specialization: Immunology

Google Scholar link: https://scholar.google.com/citations?pli=1&authuser=1&user=WrftvwoAAAAJ

ORCID iD: https://orcid.org/0000-0003-4535-2846


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 Publications

  • Mutiso JM, Gitonga CM, Gicheru MM. (2023). TGF-β levels significantly increases in patients with stage III and IV breast cancer and can be explored as a target for tumour diagnosis and staging. Scandinavian Journal of Immunology. WILEY May 2023, DOI: 10.1111/sji.13280.
  • Peter S, Mutiso J, Kariuki S. (2023). Evaluation of Intervention Measures on Controlling the Dissemination of Nontyphoidal Salmonella Disease in Mukuru Informal Settlement, Nairobi County, Kenya. British Journal of Healthcare and Medical Research - Vol. 10, No. 1 Publication Date: February 25, 2023 DOI:10.14738/jbemi.101.14073
  • Mutiso JM, Gitonga C, Abdullahi, B, Simbauni J, Gicheru MM. (2023). Alarming Cases of Cancer in Kenya: A Case for Meru and Tharaka Nithi Counties.  British Journal of Healthcare and Medical Research 10(1): Publication Date: January, 25, 2023.  DOI:10.14738/jbemi.101.13825.
  • Mogaka MD, Mutiso JM, Macharia JC, Ayako RM, Osero M and Gicheru MM. (2022). Evaluation of the Therapeutic Potential of Warburgia ugandensis, Prunus africana, and Piliostigma thonningii against Leishmania donovani in vitro and in Balb/c Mice  Journal of Zoological Research  4(4):  DOI: https://doi.org/10.30564/jzr.v4i4.4926.
  • Maundu A, Munguti J, Mutiso J, Kasozi N, Liti D and Sharma R. (2022). Effect of replacing freshwater shrimp meal (Caridina nilotica) protein with a mixture of plant protein on growth, apparent digestibility, and economic returns of Nile tilapia (Oreochromis niloticus L.).  Journal of Agricultural Extension and Rural Development 14(3): 140-147. DOI: 10.5897/JAERD2022.1328.
  • Abdullahi B, Mutiso J,  Maloba F, Macharia J, Riongoita M, Gicheru M. (2022). Climate Change and Environmental Influence on Prevalence of Visceral Leishmaniasis in West Pokot County, Kenya. Journal of Tropical Medicine, Volume 2022, Article ID 1441576, 6 pages. https://doi.org/10.1155/2022/1441576.
  • Muendo CM, Mutiso JM, Gicheru MM (2021).  Safety and Efficacy of Prosopis juliflora Leaf Extract as a Poten-tial Treatment against Visceral Leishmaniasis in Balb/c Mice.  Iranian Journal of  Parasitology 16 (4): 652-662.
  • Peter SK, Mutiso JM, Ngetich M, Mbae C, Kariuki S (2023) Seroprevalence of non-typhoidal Salmonella disease and associated factors in children in Mukuru settlement in Nairobi County, Kenya. PLoS ONE 18(7): e0288015. https://doi.org/10.1371/journal.pone.0288015.
  • Mutua PM, Mutiso JM, Simabuni JA, Gicheru MM.  (2021). Teachers’ Perception On COVID-19 Vaccine:  Implications on COVID-19 Prevention in Kenya. Journal of Vaccinology 3(1):1-5.
  • Muia D, Gicheru M,  Mutiso J, Mwangi B, Kavinda L, Kairu E,  (2021).  Effects of Extreme Flooding of Lake Baringo on Livelihoods of Communities Lining around the Lake. Advances in Applied Sociology 11: 404-414.
  • Ayako RM,  Mutiso JM, Macharia JC,  Langoi D, Ochola L. (2021). Concomitant Infection with Leishmania donovani and Plasmodium berghei Causes Pro-inflammatory Polarization Resulting in Malaria Exacerbation in BALB/c Mice.  American Journal of Infectious Diseases and Microbiology 9: 71-82.
  • Buuri M, Gicheru M, Mutiso J, Mulakoli, F. (2021). Survey of urinary aflatoxin levels among residents of Makueni County, Kenya: A follow-up study. East Africa Science 3: 67-76
  • Sagini Nicah NS, Klika, KD, Orry A, Mutiso JM, Berger MR. (2020). Pancreatic adenocarcinoma cells express proteins with lectin-like properties, some of which are modulated by exposure to riproximin. Frontiers in Pharmacology, doi: 10.3389/fphar.2020.549804.
  • Mutiso JM, Georges RB, Saginin M, Berger MR (2019). Riproximin suppresses NF-κB and ligates FAS/CD95 receptor leading to apoptosis in MDA-MB-231 and SW-707 cancer cells. International Journal of Medical Research and Pharmaceutical Sciences 6(2): 1-14.
  • Njeru A, Mutiso J, Kimutai A, Mibei EK. (2019). Performance of Rapid Immunochromatographic Test on Malaria Infection Among Expectant Women in Kericho County, Kenya. European Scientific Journal 15: 330-342. No.6 ISSN: 1857 – 7881 (Print) e - ISSN 1857- 7431.
  • Macharia JC, Mutiso JM, Gicheru MM, Ogwayo IO, Ngatiri GG. (2018). Kala-Azar And The Associated Factors Influencing Health Care Seeking Among The Residents Of Baringo County, Kenya. Researchjournali’s Journal of Public Health 4 (7): 1
  • Ogise J, Mumo R, Nyachieo A, , Mutiso J, Kamau J, Onkoba N. (2016). Adjuvants in malaria vaccine development strategies: a review. Pathogen & Infectious Disease 2016; 2: e1259. doi: 10.14800/pid.1259.
  • Gitonga CM, Mutiso JM, Gicheru MM. (2016). Performance of Widal Test and Stool Culture as Diagnostic Methods for Salmonella typhi Infection. The African Journal of Health Sciences 29 (3).
  • Mwololo SW, Mutiso JM, Macharia JC, Bourdichon AJ, Gicheru MM. (2015) In vitro activity and in vivo efficacy of a combination therapy of diminazene and chloroquine against murine visceral leishmaniasis. Journal of Biomedical Research 29(3):214-223.
  • Mwangi JN, Ozwara HS, Mutiso JM, Gicheru MM(2015) Characterization of Tunga penetrans Antigens in Selected Epidemic Areas in Murang’a County in Kenya. PLoS Neglected Tropical Diseases 9(3): e0003517. doi:10.1371/journal.pntd.0003517.
  • Laban LT, Anjili CO, Mutiso JM, Ingonga J, Kiige SG, Ngedzo MM, Gicheru MM. (2015) Experimental therapeutic studies of Solanum aculeastrum Dunal. on Leishmania major infection in BALB/c mice. Iranian Journal of Basic Medical Sciences 18: 64-71.
  • Kiige SG, Mutiso JM, Laban LT, Khayeka-Wandabwa C, Anjili CO, Ingonga J, Gicheru MM. (2014). F1 Cross-Breed Between Susceptible BALB/c and Resistant Swiss mice Infected with Leishmania major Exhibit an Intermediate Phenotype for Lesion Sizes and Type 1 Cytokines but Show Low Level of Total IgG Antibodies. Scandinavian Journal of Immunology 79: 283–291.
  • Mutiso JM, Macharia JC, Gicheru MM, Ozwara H. (2013). Immunology of leishmaniasis. Science Parasitology 14(2):51-61.
  • Mutiso JM, Macharia JC, Kiio MN, Mucheru PM, Onkoba WN, Maloba FC, Gicheru MM. (2013). Leishmania parasite specific CD4+ synergizes and correlates positively with CD8+ T cells in the production of gamma interferon following immunization of the vervet monkey (Chlorocebus aethiops) model. Science Parasitology 14(1):7-19. Mutiso JM, Macharia JC, Kiio MN,
  • Ichagichu JM, Rikoi H, Gicheru MM (2013) Development of Leishmania vaccines: predicting the future from past and present experience. Journal of Biomedical Research 27(2): 85-102.
  • Mutiso JM, Macharia JC, Taracha E, Gicheru MM (2012) Immunization with Leishmania vaccine-Alum-BCG and montanide ISA 720 adjuvants induces low-grade type 2 cytokines and high levels of IgG2 subclass antibodies in the vervet monkey (Chlorocebus aethiops) model. Scandinavian Journal of Immunology 76: 471-477.
  • Mutiso JM, Macharia JC, Taracha E, Gicheru MM (2012) Leishmania donovani whole cell antigen delivered with adjuvants protects against visceral leishmaniasis in vervet monkeys (Chlorocebus aethiops). Journal of Biomedical Research 26(1):8-16.
  • Mutiso JM, Macharia JC, Taracha E, Wafula K, Rikoi H, Gicheru MM (2012) Safety and skin delayed-type hypersensitivity response in vervet monkeys immunized with Leishmania donovani sonicate antigen delivered with adjuvants. Revista do Instituto de Medicina Tropical de São Paulo 54(1):37-41.
  • Mutiso JM, Macharia JC, Barasa M, Taracha E, Bbourdichon AJ, Gicheru MM (2011) In vitro and in vivo antileishmanial efficacy of a combination therapy of diminazene and artesunate against Leishmania donovani in BALB/c mice. Revista do Instituto de Medicina Tropical de São Paulo 53(3):129-132.
  • Mutiso JM, Macharia JC, Mutisya RM, Taracha E (2010) Subcutaneous immunization against Leishmania major infection in mice: Efficacy of formalin-killed promastigotes combined with adjuvants. Revista do Instituto de Medicina Tropical de São Paulo 52(2):95-100.
  • Mutiso JM, Macharia JC, Kariuki TM, Gicheru MM (2009) Montanide ISA 720 is more effective than BCG as an adjuvant for Leishmania killed vaccine in BALB/c mice. International Journal of Integrative Biology 7(2): 107-116.
    Curriculum vitae Joshua MUTISO Page 7 of 7
  • Mutiso JM, Macharia JC, Gicheru MM (2010) A review of adjuvants for Leishmania vaccine candidates. Journal of Biomedical Research 24(1): 16-25.
    Barasa M, Mwangi I, Mutiso JM, Kagasi AE, Ozwara SH, Gicheru MM (2010) Plasmodium knowlesi H strain pregnancy malaria immune responses in Olive baboons (Papio anubis). International Journal of Integrative Biology 10(1): 54-58.

 TRAININGS AND SCHOLARLY PRESENTATIONS AT CONFERENCES /WORKSHOPS /SEMINARS

  • Conference on ‘The 28th LEAP (Leishmaniasis East Africa Platform) Meeting’ held on October 29-30, 2023 at the Lake Naivasha Resort in Naivasha, Kenya. Theme: LEAP@20: Innovation to Foster Elimination of Visceral Leishmaniasis in Africa (Courtesy of DNDi East Africa).
  • Workshop on, ‘Building institutional capacities on genetic engineering and biotechnology research in African universities and research institutions’, Egerton University, ARC Hotel,  16th -17th, August, 2023: Organised by Egerton University and Michigan State University, USA.
  • Conference on Basic and Applied Sciences, 16th – 18th November 2022, BSSC, Kenyatta University. Theme: Embracing Science and technology for resilience and Transformation. Organized by the School of Pure and applied Sciences.
  • The 6th International conference on Beyond Science Initiative- Science and Society, February 2021. Conference paper: Concomitant Infection with Leishmania donovani and Plasmodium berghei reduces disease severity in BALB/c mice.
  • Evaluation of Carcinoembryonic and Tn antigens as potential targets of   the type II ribosome inactivation protein Riproximin in gastrointestinal and breast cancers – Presented at a Scientific Meeting at Regensburg, Germany, 25-27th April 2018.
  • The Fifth African Higher education week and RUFORUM Biannual Conference 2016. 17th – 21st October, 2016, Century City Conference Center, South Africa. Paper Presented: Fish Parasites and Their Effects on Fish Production in Relation to Extreme Flooding of Lake Baringo, Kenya.
  • The 9th Federation of African Immunological Societies (FAIS) Conference, November 30th to December 4th - 2014, Safari Park Hotel, Nairobi. Research Paper Presented:  Plasma interferon gamma and interleukin-10 levels in HIV-1 and Hepatitis C virus mono-and Co-infected people who inject drugs from Mombasa, Kenya.
  • Sustainable Development through effective knowledge sharing: Concepts, Methods and Processes, 20th to 22nd October 2020. A Virtual Workshop organized by the Center for International Migration and Development, Germany.
  • VTK: Introduction into Gene Technology Regulations in the Animal Facility RG1/RG2, 15th October 2018 – The German Cancer Research Center, Heldelberg, Germany.
  • Introductory Course for Working with Laboratory Animals, 15th – 17th October 2018, German Cancer Research Center (DKFZ) Heidelberg, Germany.
  • Teaching Methodology Course, 28th May – 14th November 2013: Centre for Teaching Excellence and Evaluation, Kenyatta University.
  • International Workshop: International Centre for Genetic Engineering and Biotechnology (ICGEB), October 24th to 26th 2012, ICGEB Conferences Unit, Padriciano, Trieste, Italy: Presented Scientific Research Paper entitled: ‘Immunization with Leishmania vaccine-alum-BCG and montanide ISA 720 adjuvants induces low grade type 2 cytokines and high levels of IgG2 subclass antibodies in the vervet monkey (Chlorocebus aethiops) model’.
  • International Workshop: ‘One Health: Understanding human and veterinary diseases from molecular cell biology to successful interventions’: Young Biomedical/Veterinary Scientists in East Africa, Sokoine University, Morogoro, Tanzania, 1st – 7th August 2011: Presented Scientific Research Paper entitled: In vitro and in vivo antileishmanial efficacy of a combination therapy of diminazene and artesunate against Leishmania donovani in BALB/c mice.
  • International Workshop on Immunology of Major Tropical Parasitic Diseases, Institute of Primate Research, 7th - 18th March 2011. Participated as a Trainer on ‘Immunology of leishmaniasis’.
  • 18th Institute of Primate Research International Biomedical Research Conference held at the Kenya Institute of Education, Nairobi-Kenya, 6th – 8th July 2010. THEME: Translating Non- Human Primate Studies into Clinical benefits for Humans. Presented Scientific Research Paper: Vaccine Development Against visceral Leishmaniasis in Non-Human Primate Model: Use of high Potential Adjuvants.
  • Immunology of Parasitic Diseases, Seattle Biomedical Research Institute, East African Regional Workshop, July 12th to 23rd 2010, Sokoine University of Agriculture, Morogoro, Tanzania.
  • The 2010 Advanced Course in Immunology, American Association of Immunologists (AAI), July 25th to 30th 2010, University of Minnesota, Minneapolis USA.
  • Effective Project Planning and Evaluation in Biomedical Research, July 24th to 27th 2010, Institute of Primate Research (IPR) in Collaboration with UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), Institute of Primate Research, Karen, Nairobi, Kenya.
  • The 18th  Postgraduate Seminar-Masters graduants, Kenyatta University, Science complex SC I: 8th- 9th June 2009. THEME: Moving research from laboratory to the communities: The challenges by Institutions of higher learning in Kenya. PAPER PRESENTED: Montanide ISA 720 is more effective than BCG as an adjuvant for Leishmania killed vaccine in BALB/c mice. International Journal of Integrative Biology 7(2): 107-116.
  • The 1st Kenyatta University Research Conference, Kenyatta University, Nairobi, Kenya, Science complex SC I: 28TH-30TH April 2009: THEME: Moving research to wealth creation. THESIS RESEARCH WORK PRESENTED: Evaluation of BCG, Montanide ISA 720 and Alum as adjuvants for leishmania vaccine in BALB/c mice.
  • Report Writing Skills for Donor Funded Research and other Projects, September 15th to 18th 2009, Center for Capacity Development in Higher Education, Kenyatta University, Nairobi, Kenya.
  • Awareness Training on ISO 9000:2000, August 1st 2008, Institute of Primate Research, Nairobi, Kenya.
  • The 17TH Institute of Primate Research Scientific Conference, Kenya College of
  • Communications Technology, Nairobi Kenya, 14TH-15TH November 2007: THEME: Integrated biomedical research and conservation for sustainable development. POSTER PRESENTED: Evaluation of BCG, Montanide ISA 720 and Alum as adjuvants for leishmania vaccine in BALB/c mice.
  • FACSCalibur Clinical CD4 Good Laboratory Practice, November 20th to 24th 2006, Becton Dickinson Biosciences – East Africa, KEMRI/BD Training Centre, KEMRI, Nairobi, Kenya.